Piperazine skeleton in the structural modification of natural products: a review

Piperazine skeleton in the structural modification of natural products: a review

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Piperazine moiety is a cyclic alphaville clothing molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms.Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications.Over 100 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antioxidant, and other activities, were reviewed.This article reviewed investigations regarding piperazine groups for the modification of natural product derivatives in the last decade, highlighting parameters that affect their borstlist självhäftande biological activity.